The cockatrice, hatched from the egg of a rooster that was sat upon by a toad. It's basically a rooster with a lizard/dragon tail that can kill you by looking into your eyes or breathing on you.
One of my favorites, the manticore. A lion's body with a human face and poison-barbed tail. So cuddly.
My favorite thing to draw are creatures; whether fantasy or cryptozoological. Awesome fun!